BIOLOGICAL AGING
HOW FAST ARE YOU AGING?
Your chronological age tells you how long you've been alive.
But people of the same chronological age can have very different levels of health, physical function and disease risk.
Chronological age measures time.
Biological age attempts to measure how your body is aging.
Understanding that difference gives us another way to think about longevity—not simply how old you are, but how you are aging.
YOU HAVE TWO AGING CLOCKS
CHRONOLOGICAL AGE
How long you have been alive.
Your chronological age is determined by your date of birth.
It moves forward at essentially the same rate for everyone and remains one of the strongest predictors of many chronic diseases.
But chronological age alone cannot tell us why two 60-year-olds may have dramatically different health, physical capacity and disease risk.
BIOLOGICAL AGE
How your body is aging.
Biological aging reflects changes occurring across your cells, tissues and organ systems over time.
Genetics plays a role, but so do factors such as:
Exercise · Nutrition · Sleep · Smoking · Alcohol · Metabolic Health · Cardiovascular Health · Inflammation · Environmental Exposures
This helps explain why two people born on the same day may not be aging in the same way.
BIOLOGICAL AGE IS ONLY PART OF THE STORY
Your age tells us where you are. Your pace of aging tells us how quickly you're getting there.
Knowing that your estimated biological age is younger or older than your chronological age is interesting.
But an equally important question is:
How fast are you aging right now?
DunedinPACE™ is an epigenetic measure designed to estimate the current pace of biological aging.
The result is expressed relative to one chronological year.
A value of 1.0 represents approximately one year of biological aging for each chronological year.
A value below 1.0 represents a slower measured pace of aging.
A value above 1.0 represents a faster measured pace of aging.
This gives us something potentially more useful than simply asking:
“How old is my body?”
We can also ask:
“How quickly is my body aging?”
NOT EVERY PART OF YOUR BODY AGES THE SAME WAY
ORGAN-SYSTEM AGING
A single whole-body biological-age number can hide important differences.
Your cardiovascular system may not be aging at the same rate as your brain, kidneys, liver or immune system.
Modern epigenetic testing can provide estimates across multiple physiological systems.
TruDiagnostic's SYMPHONYAge™ evaluates aging patterns across organ and biological systems including:
Heart
Brain
Lungs
Liver
Kidneys
Immune System
Metabolic System
Musculoskeletal System
Hormonal System
Blood
Inflammatory System
This begins to change the question from:
“What is my biological age?”
to:
“Where might aging be occurring faster—and what can I learn from it?”
HOW DO WE MEASURE BIOLOGICAL AGING?
EPIGENETICS
Your DNA contains the genetic instructions you were born with.
But how those instructions are regulated changes throughout life.
One way scientists study these changes is through DNA methylation—chemical modifications associated with patterns of gene regulation and biological aging.
By analyzing methylation patterns across the genome, researchers have developed epigenetic clocks designed to estimate different aspects of biological aging.
These tools do not predict exactly how long you will live.
Instead, they provide another layer of information that can be considered alongside your biomarkers, fitness, body composition, medical history and other measures of health.
MEET TRUAGE™
Measure your biological age. Measure your pace. Look deeper.
RENU MD uses TruDiagnostic TruAge™ for epigenetic biological-aging assessment.
A TruAge assessment can provide several different perspectives on aging:
OMICmAge™
An estimate of your biological age.
DunedinPACE™
An estimate of your current pace of biological aging.
SYMPHONYAge™
Epigenetic aging estimates across multiple organ and biological systems.
The report also includes additional epigenetic information related to immune function, inflammation and lifestyle exposures.
[ VIEW A SAMPLE TRUAGE REPORT ]
[ GET TRUAGE ]
A SINGLE RESULT IS A SNAPSHOT
THE REAL VALUE MAY BE IN THE TRAJECTORY.
Finding out your biological age once is interesting.
Following it over time may be more useful.
Exercise changes.
Fitness changes.
Body composition changes.
Sleep changes.
Metabolic health changes.
Cardiovascular risk changes.
Lifestyle changes.
The question is whether measurable aspects of your biological aging change with them.
MEASURE → ACT → TRACK → REASSESS
Rather than treating biological age as a score to celebrate or fear, we view it as one measurement within a much larger longevity profile.
BIOLOGICAL AGE IS NOT YOUR DESTINY
AND IT IS NOT YOUR ENTIRE HEALTH STORY.
No biological-age test can tell you everything about your health.
A favorable biological-age result does not mean you are free of cardiovascular disease, cancer risk, metabolic dysfunction or neurodegenerative risk.
And an unfavorable result should not be viewed as a diagnosis.
That's why biological aging should be considered alongside objective measurements such as:
ApoB & Lp(a)
Glucose & HbA1c
DEXA & Visceral Fat
VO₂ Max
Strength
Cardiovascular Imaging
Cancer Screening
Family & Personal History
The objective is not to reduce your health to one number.
It's to understand the whole picture.
FROM BIOLOGICAL AGE TO LYVYNG
Measurement should lead to action.
Biological aging is one piece of the broader longevity framework we're building with LYVYNG.
LYVYNG brings together your risks, biomarkers, testing, fitness, body composition, lifestyle and Four Horsemen assessments to help answer three fundamental questions:
Where am I now?
What should I do next?
Am I changing my trajectory?
[ EXPLORE LYVYNG ]
DON'T JUST COUNT THE YEARS.
MEASURE HOW YOU'RE AGING.
Establish your baseline.
Understand your pace of aging.
Follow your trajectory.